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Multidisciplinary Approach for the Management of Penoscrotal Extramammary Paget's disease -An eUROGEN study
Michelle Christodoulidou1, Hussain M Alnajjar1, Arie Parnham1
1Male Genital Cancer Centre, Institute of Andrology, University College London Hospital, 235 Euston Road, London, NW1 2BU, UK.
Introduction:
We reviewed the medical and surgical management and long-term outcomes for patients diagnosed with penoscrotal extramammary Pagets disease (EMPD) within an eUROGEN centre.
Patients And Methods:
Retrospective review of cases from an institutional database with biopsy proven penoscrotal EMPD.
Results:
A total of 10 patients were identified with penoscrotal EMPD over a 10-year period. Two patients had a previous history of gastrointestinal and urogenital cancers (20%) and no synchronous or metachronous cancers were identified. Eight patients with non-invasive EMPD (80%) underwent wide local excision of the affected skin, with at least a 5mm macroscopic resection margin and in selected cases simultaneous multiple mapping biopsies around the lesion were performed. Residual disease was present at the margins in seven patients (87.5%), of which three required further surgical excision or adjuvant topical immunotherapy (42.8%). Recurrence after complete excision was 12.5% and was successfully treated with topical imiquimod immunotherapy and CO2 laser therapy. Two patients (20%) had invasive carcinoma and metastatic disease at diagnosis.
Conclusion:
Reported recurrence rates of non-invasive penoscrotal EMPD are high and residual disease is present in most cases requiring either close clinical surveillance or adjuvant treatment. We propose an algorithm in the management of this rare disease.
