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SARS-CoV-2 Among Infants <90 Days of Age Admitted for Serious Bacterial Infection Evaluation

Michal Paret1, Karim Lalani2, Carine Hedari1

  • 1Division of Pediatric Infectious Diseases.

Pediatrics
|July 1, 2021
PubMed

Insights

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was common in infants hospitalized for serious bacterial infection (SBI) evaluation during high community spread. Most infected infants did not require intensive care.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Epidemiology

Background:

  • Young infants hospitalized for serious bacterial infection (SBI) evaluations may be at risk for SARS-CoV-2 infection.
  • Understanding the prevalence and clinical characteristics of SARS-CoV-2 in this population is crucial for appropriate management.

Purpose of the Study:

  • To determine the prevalence of SARS-CoV-2 in infants under 90 days old hospitalized for SBI evaluation.
  • To characterize the clinical presentation of SARS-CoV-2 infection in these young infants.

Main Methods:

  • Retrospective chart review of infants <90 days old hospitalized for SBI evaluation.
  • Study conducted across 4 New York City inpatient facilities from March to December 2020.

Main Results:

  • 15% (22/148) of infants tested positive for SARS-CoV-2.
  • Infants admitted during high community SARS-CoV-2 circulation had a 31% positive rate, versus 3% during low circulation (P < .001).
  • Fever was the most common symptom (59%); SARS-CoV-2 positive infants were less likely to have positive cultures or require intensive care.

Conclusions:

  • SARS-CoV-2 was prevalent in young infants hospitalized for SBI evaluation during periods of high community transmission.
  • Clinical presentation often included isolated fever, and most did not require intensive care admission.
Abstract

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