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Updated: Oct 31, 2025

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Published on: October 15, 2019
Construction of 7-Diethylaminocoumarins Promoted by an Electron-Withdrawing Group
Chisato Yoshikawa1, Hiroaki Ishida1, Nami Ohashi1
1Showa Pharmaceutical University.
Abstract:
The coumarin skeleton has been a focus of attention for many years, and its fluorescence properties vary depending on the substituents. Fluorescent coumarin derivatives are useful tools for many strategies have been developed for their synthesis. Although 7-diethylaminocoumarin has excellent fluorescence properties, it is unstable. We have developed a facile strategy for the synthesis of 7-diethylaminocoumarin derivatives by increasing the electrophilicity of the ynone moiety to promote nucleophilic addition reactions and cyclization. The reaction tolerates a variety of substitutions at the 4-position.
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