Characterization of Ibuprofen-Loaded MgO by One-Step Mid- and Far-FT-IR Spectroscopy

One-step mid- and far-Fourier-transform (FT)-IR spectroscopy is a facile and powerful tool that provides various information regarding chemical and crystal states. However, its potentially high applicability has not been sufficiently demonstrated. In the present study, ibuprofen (IB)-loaded MgO samples are prepared via different methods, and they are evaluated using scanning electron microscopy (SEM), thermogravimetry-differential thermal analysis (TG-DTA), X-ray diffraction analysis (XRD), N₂ adsorption-desorption measurement, CO₂ temperature-programmed desorption technique (CO₂-TPD), and FT-IR spectroscopy. The obtained results indicate that IB becomes ionized, amorphous, and/or dispersed by using MgO. Since the CO₂-TPD result shows that MgO possesses basic surfaces, it is considerable that acid-base interactions cause the above different chemical states. Furthermore, the FT-IR spectra in mid- and far-IR regions also suggest that the above physical and chemical properties of IB-loaded MgO changes through the interactions. Therefore, the characterization results suggest that one-step mid- and far-FT-IR measurements can provide valuable information regarding the chemical and crystal states.