Relationships Between Perivascular Adipose Tissue and Abdominal Aortic Aneurysms
Tongtong Ye1,2, Guangdong Zhang1, Hangyu Liu3
1Department of Endocrinology, Affiliated Hospital of Weifang Medical University, Weifang, China.
Frontiers in Endocrinology
|July 1, 2021
Summary
Perivascular adipose tissue (PVAT) contributes to abdominal aortic aneurysm (AAA) development. Targeting PVAT-derived factors may offer new therapeutic strategies for preventing and treating AAAs.
Area of Science:
- Cardiovascular Biology
- Adipose Tissue Biology
- Vascular Pathophysiology
Background:
- Abdominal aortic aneurysms (AAAs) are often asymptomatic, with high mortality upon rupture.
- AAA pathogenesis involves matrix degradation, inflammation, and oxidative stress.
- Excessive adipocyte accumulation in AAA walls is increasingly linked to disease progression.
Purpose of the Study:
- To review the relationship between perivascular adipose tissue (PVAT) and AAA development.
- To highlight the role of PVAT-derived factors in AAA pathogenesis.
- To explore PVAT as a potential therapeutic target for AAAs.
Main Methods:
- Literature review of studies investigating PVAT and AAA.
- Analysis of molecular and cellular mechanisms linking PVAT to AAA.
- Synthesis of evidence on PVAT's role in vascular homeostasis and disease.
Main Results:
- PVAT contributes to adipocyte accumulation in AAA walls.
- PVAT-derived cytokines, cells, and microRNAs regulate AAA development.
- Removal of PVAT has been associated with reduced AAA diameter.
- PVAT transitions from a protective to a detrimental role in pathological conditions.
Conclusions:
- PVAT plays a critical role in the development and progression of AAAs.
- PVAT-derived factors are key regulators of AAA pathogenesis.
- Targeting PVAT presents a promising therapeutic avenue for AAA prevention and treatment.
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