Related Experiment Videos
Induction of sperm abnormalities in mice by ifosfamide and trofosfamide
I Quinto1, E De Marinis, G De Dominicis
1Institute of Cellular and Molecular Biochemistry, 2nd Medical School, University of Naples, Italy.
Mutation Research
|September 1, 1988
Abstract:
The antitumor drugs ifosfamide (IF) and trofosfamide (TF) were evaluated for their capability to induce sperm abnormalities in (C3H X C57BL/6)F1 mice. A statistically significant increase in teratospermia was observed at the 35th day after 5 daily consecutive intraperitoneal injections of the drugs at doses of 25, 50, 100 mg/kg b.w. of TF and 100 mg/kg b.w. of IF. Thus, IF and TF are able to interfere with the differentiation process of spermatogenic cells.