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Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases

Li Wang1, Chao-Chao Yu2,3, Xin-Yuan Liu1

  • 1College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei, China.

Neural Plasticity
|July 1, 2021
PubMed

Insights

Microglia

Area of Science:

  • Neuroscience
  • Immunology
  • Genetics

Background:

  • Microglia-mediated neuroinflammation is a key feature of neurodegenerative diseases (NDDs) like Alzheimer's, Parkinson's, and ALS.
  • Microglia have dual roles, acting as both neuroprotective and detrimental factors in NDDs.
  • The precise mechanisms of microglial action in NDDs remain unclear.

Purpose of the Study:

  • To review the function and phenotypes of microglia in neurodegenerative diseases.
  • To elucidate the relationship between microglia, epigenetic modifications, and NDDs.
  • To explore potential intervention strategies targeting epigenetic modulation of microglia.

Main Methods:

  • Literature review focusing on microglia function, neuroinflammation, and epigenetic mechanisms in NDDs.
  • Analysis of current research on epigenetic regulation of microglia.
  • Synthesis of findings to highlight potential therapeutic avenues.

Main Results:

  • Microglia exhibit complex roles in NDDs, influenced by their phenotypes.
  • Epigenetic modifications are increasingly recognized as crucial regulators of microglial function in NDDs.
  • Understanding these epigenetic mechanisms offers new possibilities for NDD treatment.

Conclusions:

  • Modulating microglial function via epigenetic strategies presents a promising therapeutic approach for NDDs.
  • Further research into the epigenetic landscape of microglia is essential for developing effective interventions.
  • Targeting microglia epigenetics could offer novel treatments for Alzheimer's, Parkinson's, and ALS.

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