Tic Detection in Tourette Syndrome Patients Based on Unsupervised Visual Feature Learning

A clinical diagnosis of tic disorder involves several complex processes, among which observation and evaluation of patient behavior usually require considerable time and effective cooperation between the doctor and the patient. The existing assessment scale has been simplified into qualitative and quantitative assessments of movements and sound twitches over a certain period, but it must still be completed manually. Therefore, we attempt to find an automatic method for detecting tic movement to assist in diagnosis and evaluation. Based on real clinical data, we propose a deep learning architecture that combines both unsupervised and supervised learning methods and learns features from videos for tic motion detection. The model is trained using leave-one-subject-out cross-validation for both binary and multiclass classification tasks. For these tasks, the model reaches average recognition precisions of 86.33% and 86.26% and recalls of 77.07% and 78.78%, respectively. The visualization of features learned from the unsupervised stage indicates the distinguishability of the two types of tics and the nontic. Further evaluation results suggest its potential clinical application for auxiliary diagnoses and evaluations of treatment effects.