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Vitamins01:30

Vitamins

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Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
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Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

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Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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Minerals01:26

Minerals

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Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
 
Major...
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Sulfur Assimilation01:20

Sulfur Assimilation

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Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to...
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Related Experiment Video

Updated: Oct 31, 2025

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
03:19

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

Published on: June 28, 2024

560

Cobalamin deficiency in pregnancy.

Heleen Konings1, Yves Jacquemyn1

  • 1Global Health Institute Department of Obstetrics and Gynaecology Antwerp University Hospital UZA Antwerp University UA Antwerp Belgium.

Clinical Case Reports
|July 1, 2021
PubMed
Summary

Hydroxycobalamin supplementation effectively manages hereditary cobalamin deficiency, enabling uncomplicated pregnancy outcomes. Regular biochemical monitoring ensures maternal and fetal well-being throughout gestation.

Keywords:
homocysteinemethylmalonic acidpregnancyscobalamin

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Area of Science:

  • Biochemistry
  • Genetics
  • Obstetrics

Background:

  • Hereditary cobalamin deficiency (HCBD) presents a significant challenge during pregnancy.
  • Maternal HCBD can lead to severe neurological and hematological complications for both mother and fetus.
  • Timely and appropriate management is crucial for successful pregnancy outcomes.

Observation:

  • This study focuses on a case of hereditary cobalamin deficiency during pregnancy.
  • Serial biochemical follow-up was implemented to monitor the condition.
  • Hydroxycobalamin supplementation was administered as the primary therapeutic intervention.

Findings:

  • Hydroxycobalamin supplementation led to successful management of hereditary cobalamin deficiency.
  • Serial biochemical monitoring confirmed the efficacy of the treatment.
  • The pregnancy resulted in an uncomplicated outcome, with a healthy mother and infant.

Implications:

  • This case highlights the critical role of hydroxycobalamin in managing HCBD during pregnancy.
  • It underscores the importance of regular biochemical monitoring for early detection and intervention.
  • The findings support the use of this therapeutic strategy for similar cases, improving reproductive health in affected individuals.