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Dabigatran mitigates cisplatin-mediated nephrotoxicity through down regulation of thrombin pathway

Mohamed Gamal El-Din Ewees1, Mohamed Sadek Abdel-Bakky2,3, Asmaa Mostafa Ahmed Bayoumi4

  • 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt.

Journal of Advanced Research
|July 1, 2021
PubMed
Abstract

Keywords:
BUN, Blood urea nitrogenCDDP, CisplatinCisplatinCr, creatinineCrcl, Creatinine cleranceDab, DabigatranDabigatranFXa, activated form of Factor XGSH, Reduced GlutathionH&E, Hematoxylin–EosinINR, International normalized ratioKIM-1, kidney injury molecule-1PAR, protease-activated receptorPAR2Pt, Prothrombin timePtt, Partial thromboplastin timeROS, Reactive oxygen speciesSOD, Superoxide dismutaseTF, Tissue factorThrombinpERK1/2

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