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Remdesivir - Current evidence & perspective in management of COVID-19 infection

Jyoti Bajpai1, Surya Kant1, Akshyaya Pradhan2

  • 1Department of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.

Journal of Family Medicine and Primary Care
|July 1, 2021
PubMed

Insights

Remdesivir, an antiviral drug, shows promise in treating COVID-19 by inhibiting viral RNA polymerase. This review summarizes clinical trials and evidence for remdesivir

Area of Science:

  • Virology
  • Infectious Diseases
  • Pharmacology

Background:

  • COVID-19, caused by SARS-CoV-2, emerged in late 2019 and rapidly became a global pandemic.
  • The urgent need for effective treatments has driven research into various therapeutic agents.
  • Remdesivir, an investigational antiviral, has demonstrated activity against related coronaviruses.

Purpose of the Study:

  • To review and summarize existing evidence on remdesivir's efficacy and safety for treating COVID-19.
  • To analyze data from in-vitro, in-vivo, and clinical studies.
  • To assess remdesivir's potential as a therapeutic option for coronavirus disease 2019.

Main Methods:

  • Literature review of published studies and clinical trials.
  • Analysis of in-vitro and in-vivo antiviral activity data.
  • Evaluation of evidence from observational and non-randomized studies.

Main Results:

  • Remdesivir exhibits in-vitro activity against SARS-CoV-2.
  • Preclinical studies showed promising antiviral effects against SARS-CoV-1 and MERS-CoV.
  • Clinical use is based on emergency authorizations, supported by preliminary data.

Conclusions:

  • Remdesivir is a potential therapeutic candidate for COVID-19.
  • Further robust clinical trials are needed to confirm efficacy and safety.
  • Current use is primarily for moderate to severe cases under specific access programs.

Keywords:
Coronaviruspneumoniaremdesivirsevere diseasesimple study

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