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Updated: Oct 31, 2025

In Vivo Detection and Analysis of Rb Protein SUMOylation in Human Cells
Published on: November 2, 2017
Comprehensive Analysis Reveals the Potential Regulatory Mechanism Between Ub-Proteasome System and Cell Cycle in
Zhiyuan Zhang1, Jingwen Chen1, Wentao Tang1
1Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Abstract:
The ubiquitin (Ub)-proteasome system (UPS) is an important regulatory component in colorectal cancer (CRC), and the cell cycle is also characterized to play a significant role in CRC. In this present study, we firstly identified UPS-associated differentially expressed genes and all the differentially expressed protein-coding genes in CRC through three differential analyses. UPS-associated genes were also further analyzed via survival analysis. A weighted gene co-expression network analysis (WGCNA) was used to identify the cell cycle-associated genes. We used protein-protein interaction (PPI) network to comprehensively mine the potential mechanism of the UPS-cell cycle regulatory axis. Moreover, we constructed a signature based on UPS-associated genes to predict the overall survival of CRC patients. Our research provides a novel insight view of the UPS and cell cycle system in CRC.
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