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Endothelial dysfunction in COPD: a systematic review and meta-analysis of studies using different functional
Marieta P Theodorakopoulou1, Maria Eleni Alexandrou1, Dimitra Rafailia Bakaloudi1
1Dept of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
ERJ Open Research
|July 1, 2021
Summary
Patients with chronic obstructive pulmonary disease (COPD) exhibit significantly impaired endothelial function compared to healthy individuals. This endothelial dysfunction may contribute to the high rates of cardiovascular disease seen in COPD patients.
Area of Science:
- Cardiology
- Pulmonology
- Vascular Biology
Background:
- Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD).
- Endothelial dysfunction is a proposed pathogenetic mechanism linking COPD and CVD.
- This study systematically reviews and meta-analyzes functional assessments of endothelial function in COPD patients versus controls.
Purpose of the Study:
- To systematically review and meta-analyze studies evaluating endothelial function in COPD patients.
- To compare endothelial function between individuals with COPD and healthy controls.
- To identify potential factors influencing endothelial function differences.
Main Methods:
- A comprehensive literature search was conducted using PubMed and Scopus databases.
- Eligible studies included adult COPD patients and evaluated endothelial damage via functional methods.
- Study quality was assessed using the Newcastle-Ottawa scale; subgroup and sensitivity analyses were performed.
Main Results:
- Nineteen studies with 968 participants were included in the meta-analysis.
- COPD patients showed significantly impaired endothelium-dependent and -independent vasodilation compared to controls.
- Overall, pronounced endothelial dysfunction was observed in COPD patients (SMD -1.19, 95% CI -1.69 to -0.68).
Conclusions:
- Patients with COPD demonstrate significantly impaired endothelial function compared to non-COPD controls.
- Endothelial dysfunction is a key finding in COPD patients.
- Further research is needed to clarify the role of endothelial dysfunction in COPD-related cardiovascular disease development.
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