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The Eyes Absent proteins in development and in developmental disorders
Upendra Kumar Soni1, Kaushik Roychoudhury1, Rashmi S Hegde1
1Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, U.S.A.
Biochemical Society Transactions
|July 1, 2021
Summary
Eyes Absent (EYA) proteins regulate cell fate and organ development through transcriptional and phosphatase activities. Dysregulation of EYA proteins is linked to developmental disorders and cancers, impacting key signaling pathways.
Area of Science:
- Developmental Biology
- Molecular Biology
- Biochemistry
Background:
- Eyes Absent (EYA) proteins are crucial transactivator-phosphatase enzymes involved in cell-fate determination and organogenesis.
- EYA proteins possess dual activities: transcriptional regulation and protein tyrosine phosphatase function, independently influencing cellular processes.
- Aberrant EYA activity is implicated in various developmental disorders and cancers, highlighting their critical role in health and disease.
Purpose of the Study:
- To provide a comprehensive overview of the multifaceted roles of EYA proteins in embryonic development.
- To elucidate the molecular signaling pathways associated with EYA-mediated organ development.
- To highlight the connection between EYA protein dysregulation and human developmental disorders.
Main Methods:
- Literature review of existing research on EYA protein functions.
- Analysis of studies detailing EYA's involvement in cell proliferation, differentiation, and morphogenesis.
- Examination of signaling pathways modulated by EYA proteins in various developmental contexts.
Main Results:
- EYA proteins contribute to proliferation, differentiation, morphogenesis, and tissue homeostasis through distinct biochemical activities.
- EYA proteins interact with and modulate a wide array of cellular signaling pathways critical for development.
- Disruptions in EYA levels or activity correlate with a spectrum of syndromic and non-syndromic developmental abnormalities.
Conclusions:
- EYA proteins are vital regulators of development, acting through both transcriptional and enzymatic functions.
- Understanding EYA-associated signaling pathways is key to deciphering the etiology of developmental disorders and cancers.
- Further research into EYA proteins offers potential therapeutic targets for developmental abnormalities and related diseases.
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