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Related Experiment Video

Updated: Oct 31, 2025

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

Medication use and mammographic breast density.

Yunan Han^1,2, Chee Teik Lee^1,3, Shuai Xu¹

¹Department of Surgery, Division of Public Health Sciences, Washington University School of Medicine, 660 South Euclid Avenue, Campus, Box 8100, St. Louis, MO, 63110, USA.

Breast Cancer Research and Treatment

|July 1, 2021

Summary

This study found that statin use was not linked to breast density but increased non-dense breast volume. Aspirin and ibuprofen showed no association with mammographic density, suggesting these medications do not impact breast cancer risk via density changes.

Keywords:

Aspirin Breast cancer Ibuprofen Mammographic breast density NSAID Statin

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Last Updated: Oct 31, 2025

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

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Area of Science:

Biomedical research
Radiology
Oncology

Background:

Mammographic breast density is a significant risk factor for breast cancer.
Identifying factors influencing breast density can aid in breast cancer prevention strategies.
Previous research on medication effects on breast density yielded limited and conflicting results.

Purpose of the Study:

To investigate the association between the use of statins, aspirin, and ibuprofen and mammographic breast density.
To clarify the relationship between common medications and breast density, a key breast cancer risk factor.

Main Methods:

A cohort of 775 women undergoing screening mammography was analyzed.
Mammographic breast density was quantified using Volpara software.
Multivariable-adjusted linear regression models were employed to assess medication associations with breast density metrics.

Main Results:

Statin use was not associated with volumetric percent density or dense breast volume.
Statin use showed a positive association with non-dense breast volume (p trend = 0.02).
No statistically significant associations were found between aspirin or ibuprofen use and mammographic breast density.

Conclusions:

Medication use, specifically statins, aspirin, and ibuprofen, was not linked to volumetric percent density or dense breast volume.
Statin use was positively associated with non-dense breast volume.
The findings suggest that potential links between these medications and breast cancer risk are unlikely to be mediated by changes in mammographic breast density.