Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

549
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
549
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

317
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
317
Seizures: Classification01:13

Seizures: Classification

837
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
837
Psychosurgery01:30

Psychosurgery

155
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
155
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

855
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
855

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Socioeconomic status and epilepsy surgery in the United States: Timing and outcomes.

Epilepsia·2026
Same author

Moving artificial intelligence from research to real-world clinical use in neurology.

Nature reviews. Neurology·2026
Same author

Fully automated three-dimensional deep learning-based magnetic resonance imaging segmentation of brain cavities in epilepsy surgery.

Epilepsia·2026
Same author

Pediatric epilepsy surgery: Global survey of referral and presurgical evaluation practices.

Epilepsia·2026
Same author

Consistency of Ictal Epileptogenic Foci in Children With Tuberous Sclerosis Complex and Its Clinical Predictors.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same author

AES ILAE North America Symposium: Guiding Evidence-Based Epilepsy Management.

Epilepsy currents·2026

Related Experiment Video

Updated: Oct 31, 2025

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.6K

Does etiology really matter for epilepsy surgery outcome?

Lara Jehi1, Kees Braun2

  • 1Epilepsy Center, Cleveland Clinic, Cleveland, OH, USA.

Brain Pathology (Zurich, Switzerland)
|July 1, 2021
PubMed
Summary

Epilepsy histopathology significantly impacts epilepsy surgery outcomes, affecting both seizure control and cognitive function. Understanding these underlying causes is crucial for improving patient care and surgical success.

Keywords:
cognitive outcomesepilepsy surgeryhistopathologyprognosisseizure outcomes

More Related Videos

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

1.3K
Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE
06:04

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

1.2K

Related Experiment Videos

Last Updated: Oct 31, 2025

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.6K
Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

1.3K
Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE
06:04

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

1.2K

Area of Science:

  • Neurology
  • Neurosurgery
  • Pathology

Background:

  • Epilepsy surgery outcomes are influenced by various factors, including clinical, imaging, and electrophysiological data.
  • The role of epilepsy histopathology in predicting surgical outcomes remains under-explored.

Purpose of the Study:

  • To review the literature on the relationship between epilepsy etiology (histopathology) and post-surgical outcomes.
  • To determine if histopathology causally influences seizure and cognitive outcomes after epilepsy surgery.
  • To explore potential mechanisms linking histopathology to surgical outcomes.

Main Methods:

  • Systematic review of existing literature.
  • Analysis of studies correlating epilepsy histopathology with seizure and cognitive outcomes.
  • Evaluation of evidence for a causal relationship between etiology and surgical results.

Main Results:

  • Histopathology is a significant, yet often under-recognized, determinant of epilepsy surgery success.
  • Specific etiologies are associated with varying degrees of seizure reduction and cognitive improvement.
  • Evidence suggests a causal link between underlying brain pathology and surgical outcomes.

Conclusions:

  • Epilepsy etiology plays a critical role in predicting seizure and cognitive outcomes following surgery.
  • Further research into the mechanistic pathways is needed to develop targeted therapies and biomarkers.
  • A deeper understanding of pathology-outcome interactions can optimize patient selection and management in epilepsy surgery.