Small Scorpion-like Peptidomimetics: Potential Broad-Spectrum Membrane Active Antimicrobials without Detectable
1School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China.
Journal of Medicinal Chemistry
|July 1, 2021
Abstract:
Peptidomimetics have been explored as potential antimicrobial agents against Gram-positive and Gram-negative bacteria. A new scorpion-like peptidomimetic, compound 12, inspired by molecular design in bioengineering, exhibited excellent antimicrobial activity and good selectivity between bacteria and human cells. In addition, compound 12 showed impressive therapeutic efficacy with 99.998% reduction in the in vivo model.
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