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Updated: Jul 14, 2026

The Forced Swim Test as a Model of Depressive-like Behavior
Published on: March 2, 2015
Antidepressants Modify Cryptic Behavior in Juvenile Cuttlefish at Environmentally Realistic Concentrations
Apolline Chabenat1,2, Thomas Knigge2, Cécile Bellanger1
1Normandie Univ, Unicaen, Univ Rennes, CNRS, Éthologie animale et humaine (EthoS)-UMR 6552, University of Caen Normandy, Caen, France.
Abstract:
Contamination of the marine environment by antidepressants may affect neurophysiological processes in nontarget organisms, such as the common cuttlefish, Sepia officinalis. The present study tested whether environmentally realistic concentrations of antidepressants, that is, fluoxetine alone (5 ng L-1 ) or cumulated with venlafaxine (2.5 or 5 ng L-1 ), affect camouflage in newly hatched cuttlefish. The results show that antidepressants improved uniform body patterns, whereas disruptive body patterns were not affected. Environ Toxicol Chem 2021;40:2571-2577. © 2021 SETAC.

