Related Experiment Video
Updated: Oct 31, 2025

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Catechol-Bearing Polyketide Derivatives from Sparticola junci
Katherine Yasmin M Garcia1,2, Chayanard Phukhamsakda3,4, Mark Tristan J Quimque1,2
1The Graduate School, University of Santo Tomas, España Boulevard, 1015 Manila, Philippines.
Abstract:
Sparticols A (1) and B (2), two catechol-bearing naphthalenedioxy derivatives, were isolated from the submerged culture of the Spanish broom inhabiting Dothideomycetes fungus, Sparticola junci. The structures of 1 and 2 were established by NMR spectroscopic analysis and high-resolution mass spectrometry. The 8S absolute configuration of their β-hydroxy functionalities was determined by ECD-TDDFT. Both compounds exhibited inhibitory activity against Staphylococcus aureus with an MIC value of 66.6 μg/mL. Polyketides 1 and/or 2 may be associated with pathways cascading to seco-spirodioxynapthalene derivatives.
Related Concept Videos
Biosynthesis in Bacteria
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry
Vicinal Diols via Reductive Coupling of Aldehydes or Ketones: Pinacol Coupling Overview
Diels–Alder Reaction Forming Cyclic Products: Stereochemistry
Bacterial Phylum Spirochaetes
Polymer Classification: Stereospecificity

![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)