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Preparation of clarithromycin floating core-shell systems (CSS) using multi-nozzle semi-solid extrusion-based 3D

Peihong Chen¹, Jinling Liu¹, Kaijun Zhang¹

¹Guangdong Pharmaceutical University, Guangzhou 510006, China.

International Journal of Pharmaceutics

|July 1, 2021

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This study introduces a novel 3D-printed core-shell system for gastric floating drug delivery, overcoming matrix erosion issues. The innovative design ensures prolonged buoyancy and sustained drug release for poorly soluble drugs.

Area of Science:

Pharmaceutical Technology
Drug Delivery Systems
3D Printing in Medicine

Background:

Matrix erosion limits the efficacy of gastric floating delivery systems (GFDDS) for poorly soluble drugs.
Sustained drug release and prolonged gastric residence time are crucial for effective GFDDS.
Conventional GFDDS often suffer from premature buoyancy loss due to matrix erosion.

Purpose of the Study:

To develop a stable core-shell system (CSS) using 3D printing to enhance buoyancy and drug release of GFDDS.
To investigate the impact of a novel floating core structure on the performance of gastric floating drug delivery.
To achieve sustained release and prolonged floating of poorly soluble drugs like clarithromycin (CAM).

Main Methods:

Fabrication of a core-shell system (CSS) using multi-nozzle semi-solid extrusion (SSE) 3D printing.

Keywords:

3D printing Clarithromycin Floating core Gastric floating Micro-airbag Poorly soluble drugs Sustained release

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Incorporation of a low-density drug-loaded shell and a buoyant floating core.

Characterization of drug loading capacity, sustained release profile, and floating behavior of the CSS.

Main Results:

The clarithromycin (CAM) loaded shell achieved a high loading capacity of 81.7%.
The fabricated CAM CSS demonstrated 74.5% (w/w) drug loading and 8-hour sustained release.
The novel floating core design provided immediate and prolonged floating (>10 hours) due to micro-airbags and CO2 generation.

Conclusions:

The 3D-printed core-shell system effectively overcomes matrix erosion challenges in GFDDS.
The innovative floating core design significantly enhances buoyancy and prolongs gastric residence time.
This core-shell structure offers a promising approach for developing stable and effective gastric floating drug delivery systems.