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Updated: Oct 31, 2025

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
Bayesian analysis of Glucose dynamics during the Oral Glucose Tolerance Test (OGTT)
Hugo Flores-Arguedas1, Marcos A Capistrán1
1Centro de Investigación en Matemáticas, A.C., Jalisco S/N, Valenciana, 36023, Guanajuato, GTO, México.
Abstract:
This paper proposes a model that considers the action and timing of insulin and glucagon in glucose homeostasis after an oral stimulus. We use the Bayesian paradigm to infer kinetic rates, namely insulin and glucagon secretion, gastrointestinal emptying, and basal glucose concentration in blood. We identify two insulin scores related to glucose concentration in both blood and the gastrointestinal tract. The scores allow us to suggest a classification for individuals with impaired insulin sensitivity.
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