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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Updated: Oct 31, 2025

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Published on: December 30, 2016

Hyperpolarized Metabolic MRI-Acquisition, Reconstruction, and Analysis Methods.

Peder Eric Zufall Larson^1,2,3, Jeremy W Gordon¹

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143, USA.

|July 2, 2021

Summary

Hyperpolarized metabolic MRI using 13C-labeled agents offers powerful in vivo real-time metabolism assessments. This review details advanced imaging methods for data acquisition, reconstruction, and analysis in hyperpolarized MRI studies.

Keywords:

fast spectroscopic imaging hyperpolarized carbon-13 MRI kinetic modeling metabolic imaging metabolite-specific imaging spectral-spatial RF pulses variable flip angles

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Area of Science:

Medical Imaging
Metabolic Research
Biophysics

Background:

Hyperpolarized metabolic MRI with 13C-labeled agents provides in vivo real-time metabolism insights.
This technique is applicable across various scales, from cells to human subjects.
Hyperpolarized agents possess unique properties requiring specialized imaging approaches.

Purpose of the Study:

To describe state-of-the-art methods for hyperpolarized metabolic MRI.
To guide the design and execution of hyperpolarized MRI studies.
To summarize current data acquisition, reconstruction, and analysis techniques.

Main Methods:

Review of advanced data acquisition strategies for hyperpolarized MRI.
Discussion of reconstruction algorithms tailored for hyperpolarized data.
Overview of analysis methods for metabolic kinetic modeling.

Main Results:

Hyperpolarized MRI enables non-invasive assessment of real-time metabolic processes.
Specialized methods are crucial due to unique agent properties like limited signal and decay.
The review synthesizes current best practices for study design and execution.

Conclusions:

Hyperpolarized metabolic MRI is a powerful tool for in vivo metabolic research.
Understanding specialized imaging methods is key to successful application.
This work provides a guide for researchers utilizing hyperpolarized MRI techniques.