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Updated: Oct 31, 2025

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

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Pathogenesis and Potential Therapeutic Targets for Triple-Negative Breast Cancer

Chia-Jung Li1,2, Yen-Dun Tony Tzeng3,4, Yi-Han Chiu5

  • 1Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan.

Cancers
|July 2, 2021
PubMed

Insights

Triple negative breast cancer (TNBC) is aggressive, but targeted therapies offer improved efficacy over chemotherapy. Research into TNBC subtypes and molecular biology is advancing treatment options for better patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Triple negative breast cancer (TNBC) is a highly aggressive and heterogeneous cancer subtype.
  • TNBC is characterized by early recurrence, invasiveness, and poor patient prognosis.
  • Current chemotherapy treatments for TNBC exhibit suboptimal efficacy.

Purpose of the Study:

  • To review the latest advancements in understanding TNBC subtypes.
  • To explore the emerging landscape of targeted therapies for TNBC.
  • To highlight the advantages of targeted therapy over traditional treatments.

Main Methods:

  • Literature review of recent studies on TNBC.
  • Analysis of research on TNBC molecular biology and subtypes.
  • Synthesis of findings on targeted therapy efficacy and application.

Main Results:

  • Significant progress has been made in identifying TNBC subtypes.
  • Targeted therapies demonstrate potential for improved efficacy and reduced toxicity.
  • New therapeutic strategies are emerging based on molecular profiling.

Conclusions:

  • Targeted therapy represents a promising frontier for TNBC treatment.
  • Further research into TNBC subtypes will refine personalized treatment approaches.
  • Advancements in targeted therapy offer hope for improved outcomes in TNBC patients.
Keywords:
biomarkersbreast cancerpathogenesistarget therapy

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