Related Experiment Video
Updated: Oct 31, 2025
06:47
Author Spotlight: A Bicelle Crystallization Setup for ABC Transporter Membrane Proteins to Advance Drug Development
Published on: August 25, 2023
1.6K
Peroxisomal ABC Transporters: An Update
Ali Tawbeh1, Catherine Gondcaille1, Doriane Trompier1
1Laboratoire Bio-PeroxIL EA7270, University of Bourgogne Franche-Comté, 6 Boulevard Gabriel, 21000 Dijon, France.
International Journal of Molecular Sciences
|July 2, 2021
Summary
Peroxisomal ATP-binding cassette (ABC) transporters, including ABCD1 and ABCD3, are crucial for lipid transport and linked to genetic disorders. Emerging research suggests their involvement in cell signaling and cancer, highlighting new therapeutic avenues.
Area of Science:
- Cell Biology
- Biochemistry
- Genetics
Background:
- ATP-binding cassette (ABC) transporters are a large protein superfamily involved in transport across membranes.
- In humans, peroxisomal ABC transporters (ABCD1, ABCD2, ABCD3) are essential for lipid metabolism.
- Defects in ABCD1 and ABCD3 cause X-linked adrenoleukodystrophy and bile acid synthesis defects, respectively.
Purpose of the Study:
- To review the structure, function, and mechanisms of human peroxisomal ABC transporters.
- To explore the link between these transporters and human pathologies, including cancer.
- To summarize models for studying these transporters and discuss their interactome.
Main Methods:
- Literature review of existing research on peroxisomal ABC transporters.
- Analysis of in vitro and in vivo studies across species.
- Examination of protein interactome data.
Main Results:
- Peroxisomal ABC transporters form functional dimers/tetramers and transport various lipids.
- ABCD1 and ABCD3 defects lead to specific genetic disorders.
- These transporters are implicated in cell signaling, cell control, and cancer.
Conclusions:
- Peroxisomal ABC transporters play vital roles in metabolism, disease, and potentially cell regulation.
- Further research into their interactome may reveal novel functions and therapeutic targets.
- Understanding these transporters is crucial for addressing associated genetic disorders and cancer.
Related Concept Videos
01:31ABC Transporters: Exporter
5.5K
ATP-binding cassette or ABC transporter is the largest superfamily of integral membrane proteins. The transporters have transmembrane-binding domains (TMDs) and nucleotide-binding domains (NBDs). The TMDs are specific to their substrates, whereas the NBDs are similar to engines that complete ATP hydrolysis to complete the substrate transport. They can be full transporters consisting of two TMDs and NBDs, half transporters with one TMD and NBD, while some encoded with a single TMD or NBD are...
5.5K
01:27ABC Transporters: Importer
3.1K
ATP-binding cassette or ABC transporters are a class of ATP-driven pumps that hydrolyze ATP to move solutes across the membrane. They can be grouped into importers and exporters. While exporters are present in all domains of life, importers exist only in bacteria and some plants.
In bacteria, based on the number of transmembrane helices and the chemical nature of their substrates, the ABC importers can be divided into three types:
In bacteria, based on the number of transmembrane helices and the chemical nature of their substrates, the ABC importers can be divided into three types:
3.1K
01:27Protein Import into the Peroxisomes
4.2K
Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
4.2K
01:06Carrier-Mediated Transport
702
Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
702
01:27ATP Driven Pumps I: An Overview
9.1K
ATP-driven pumps, also known as transport ATPases, are integral membrane proteins. They have binding sites for ATP located on the membrane's cytosolic side and the ion-conducting domain in the transmembrane region. These pumps use the free energy released from ATP hydrolysis to move the solutes across cell membranes against an electrochemical gradient.
There are four main types of ATP-driven pumps - P-type, V-type, F-type, and ABC transporter. All these pumps are of varying complexities and...
There are four main types of ATP-driven pumps - P-type, V-type, F-type, and ABC transporter. All these pumps are of varying complexities and...
9.1K
01:19Membrane Asymmetry Regulating Transporters
6.2K
Enzymes like flippase, floppase, and scramblase transfer phospholipids from one layer to another in the membrane, thereby affecting membrane asymmetry.
Flippase
Eukaryotic flippases are type-IV P-type ATPases or P4-ATPases belonging to P-type ATPase family proteins that are membrane-bound pumps involved in the ATP-mediated transport of ions and molecules across the membrane. Flippases flip specific phospholipids from the outer to the inner leaflet of a membrane. All P4-ATPases have one...
Flippase
Eukaryotic flippases are type-IV P-type ATPases or P4-ATPases belonging to P-type ATPase family proteins that are membrane-bound pumps involved in the ATP-mediated transport of ions and molecules across the membrane. Flippases flip specific phospholipids from the outer to the inner leaflet of a membrane. All P4-ATPases have one...
6.2K