Tribbles Pseudokinases in Colorectal Cancer

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Bibiana I Ferreira1,2,3, Bruno Santos1,2,4, Wolfgang Link5

  • 1Centre for Biomedical Research (CBMR), Campus of Gambelas, Universidade do Algarve, 8005-139 Faro, Portugal.

Cancers
|July 2, 2021
PubMed

Insights

Tribbles (TRIB) pseudokinases play dual roles in colorectal cancer (CRC) development, acting as oncogenes or tumor suppressors. This review consolidates knowledge on TRIB1, TRIB2, and TRIB3 in CRC, highlighting their potential as biomarkers and therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • The Tribbles (TRIB) pseudokinase family regulates critical cellular processes.
  • TRIB proteins exhibit context-dependent roles, functioning as oncogenes or tumor suppressors.
  • Their specific contributions to colorectal cancer (CRC) development require further elucidation.

Purpose of the Study:

  • To review the current knowledge on TRIB1, TRIB2, and TRIB3 in CRC.
  • To explore the potential of Tribbles proteins as biomarkers and therapeutic targets in CRC.
  • To establish a chronological timeline of research on Tribbles in CRC from 2003 to 2020.

Main Methods:

  • Systematic literature review of articles published between 2003 and 2020.
  • Focused on studies involving Tribbles and human colorectal cancer samples or cell lines.
  • Organized findings based on Tribbles amplification, overexpression, clinical significance, regulation, modulation, and downstream mechanisms.

Main Results:

  • Tribbles proteins are implicated in CRC onset and progression through amplification and overexpression.
  • Overexpression of Tribbles has clinical significance in CRC.
  • Research has explored upstream regulation, pharmacological/genetic modulation, and downstream pathways of Tribbles in CRC.

Conclusions:

  • Tribbles proteins are crucial regulators in colorectal cancer.
  • Understanding Tribbles' multifaceted roles is essential for developing novel diagnostic and therapeutic strategies.
  • Further research is needed to fully consolidate the knowledge and therapeutic potential of Tribbles in CRC.
Keywords:
biomarkercolon cancercolorectal cancergene expressiongenomic amplificationoncogenepharmacological targetpseudokinasetribbles

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