Tribbles Pseudokinases in Colorectal Cancer

Area of Science:

• Oncology
• Molecular Biology
• Biochemistry

Background:

• The Tribbles (TRIB) pseudokinase family regulates critical cellular processes.
• TRIB proteins exhibit context-dependent roles, functioning as oncogenes or tumor suppressors.
• Their specific contributions to colorectal cancer (CRC) development require further elucidation.

Purpose of the Study:

• To review the current knowledge on TRIB1, TRIB2, and TRIB3 in CRC.
• To explore the potential of Tribbles proteins as biomarkers and therapeutic targets in CRC.
• To establish a chronological timeline of research on Tribbles in CRC from 2003 to 2020.

Main Methods:

• Systematic literature review of articles published between 2003 and 2020.
• Focused on studies involving Tribbles and human colorectal cancer samples or cell lines.
• Organized findings based on Tribbles amplification, overexpression, clinical significance, regulation, modulation, and downstream mechanisms.

Main Results:

• Tribbles proteins are implicated in CRC onset and progression through amplification and overexpression.
• Overexpression of Tribbles has clinical significance in CRC.
• Research has explored upstream regulation, pharmacological/genetic modulation, and downstream pathways of Tribbles in CRC.

Conclusions:

• Tribbles proteins are crucial regulators in colorectal cancer.
• Understanding Tribbles' multifaceted roles is essential for developing novel diagnostic and therapeutic strategies.
• Further research is needed to fully consolidate the knowledge and therapeutic potential of Tribbles in CRC.