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Effectiveness and Safety of a Single-Dose Ivermectin Treatment for Uncomplicated Strongyloidiasis in Immunosuppressed

Fernando Salvador1, Ana Lucas-Dato2, Silvia Roure3

  • 1Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, 08035 Barcelona, Spain.

Pathogens (Basel, Switzerland)
|July 2, 2021
PubMed

Strongyloidiasis affects an estimated 600 million people worldwide, especially in tropical and subtropical areas. Single-dose ivermectin treatment has shown to be effective among immunocompetent patients with uncomplicated strongyloidiasis. Here, we present the protocol of the ImmunoStrong study, a prospective observational study aiming to evaluate the effectiveness and safety of a single-dose ivermectin for treatment of uncomplicated strongyloidiasis in immunosuppressed patients. The secondary objectives are to assess accuracy of molecular techniques for the follow-up of these patients and to determine the population pharmacokinetics of ivermectin. The information retrieved by this study will cover relevant information gaps in the strongyloidiasis management among immunosuppressed patients.

Keywords:
PCRStrongyloides stercoralisimmunosuppressionivermectinpopulation pharmacokinetics

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