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Cost-Effectiveness of Pertussis Vaccination Schedule in Israel

Dean Langsam1, Dor Kahana1, Erez Shmueli1

  • 1Department of Industrial Engineering, Tel-Aviv University, Tel-Aviv 6997801, Israel.

Vaccines
|July 2, 2021
PubMed

Insights

Optimizing the pertussis vaccination schedule in Israel by shifting the first booster to age six can decrease hospitalizations. Increased maternal vaccination coverage is cost-effective, while the second booster

Area of Science:

  • Epidemiology
  • Public Health
  • Infectious Disease Modeling

Background:

  • Pertussis is a highly contagious bacterial illness predominantly impacting infants.
  • Optimizing vaccination schedules is crucial for disease control and resource allocation.

Purpose of the Study:

  • To evaluate the cost-effectiveness of alternative pertussis vaccination strategies in Israel.
  • To determine the optimal timing for booster doses and assess maternal vaccination impact.

Main Methods:

  • Development of an age-structured mathematical model for pertussis transmission.
  • Calibration of the model using 16 years of Israeli pertussis case data.
  • Projection of costs and quality-adjusted life years (QALYs) for various intervention scenarios.

Main Results:

  • Shifting the first pertussis booster dose from age seven to six is predicted to be optimal, reducing outpatient visits and hospitalizations.
  • Increased maternal vaccination coverage demonstrates high cost-effectiveness ($77,000–$97,000 per QALY).
  • The second booster dose shows limited cost-effectiveness (0.6 probability at $110,000/QALY).

Conclusions:

  • Maternal pertussis vaccination should be prioritized and encouraged.
  • The first booster dose recommendation should be moved to age six.
  • The necessity of the second booster dose warrants careful consideration.

Keywords:
cost-effectiveness analysispertussispopulation modeltransmission modelvaccine allocationwaning immunity

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