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Healthcare Associated Infections II: Preventive Measures01:22

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Updated: Oct 31, 2025

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Decrease in All-Cause 30-Day Mortality after Bacteraemia over a 15-Year Period: A Population-Based Cohort Study in

Mona Katrine Alberthe Holm1, Filip Jansåker2,3, Kim Oren Gradel4,5

  • 1Department of Clinical Microbiology, Copenhagen University Hospital Hvidovre, Kettegaard Alle 30, 2650 Hvidovre, Denmark.

International Journal of Environmental Research and Public Health
|July 2, 2021
PubMed
Summary
This summary is machine-generated.

Mortality from bloodstream infections (bacteraemia) decreased significantly between 2000 and 2014. This study tracked 30-day mortality trends in Denmark, showing a positive impact on patient outcomes.

Keywords:
bacteraemiabloodstream infectionepidemiologymortalitypopulation-based study

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Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Public Health

Background:

  • Bacteraemia is a common infection with significant impact on patient morbidity and mortality.
  • Global incidence of bacteraemia is on the rise, necessitating ongoing research into mortality trends.
  • Understanding mortality patterns is crucial for public health strategies and clinical management.

Purpose of the Study:

  • To investigate trends in all-cause 30-day mortality following bacteraemia.
  • To analyze mortality rates in relation to the incidence of bacteraemia episodes and the general population.
  • To assess changes in mortality over a 15-year period in Denmark.

Main Methods:

  • Retrospective analysis of clinically significant bacteraemia episodes (n=55,257) from 2000-2014.
  • Utilized population-based data from two Danish healthcare regions covering approximately 2.4 million inhabitants.
  • Assessed all-cause 30-day mortality, bacterial species, and vital status.

Main Results:

  • A significant decreasing trend in all-cause 30-day mortality was observed from 2000 to 2014.
  • Mortality per bacteraemia episode decreased from 22.7% to 17.4% annually.
  • Mortality per 100,000 inhabitants decreased from 41 to 39 over the study period.

Conclusions:

  • All-cause 30-day mortality in patients with bacteraemia has significantly declined over 15 years.
  • The findings indicate successful interventions or improved management strategies for bacteraemia.
  • Continued monitoring of bacteraemia mortality is essential for public health surveillance.