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Benign melanocytic lesions. A morphometric analysis.

A Giannini1, C Urso, M Santucci

  • 1Istituto di Anatomia e Istologia Patologica, Università di Fireñze, Italy.

Pathology, Research and Practice
|June 1, 1988
PubMed
Summary
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Melanocyte nuclei in skin lesions grow larger and rounder as they evolve from lentigines to dermal nevi. This nuclear maturation process, observed across skin levels, may also occur in malignant melanomas.

Area of Science:

  • Dermatopathology
  • Cell Biology
  • Histology

Background:

  • Melanocytic nevi represent a spectrum of benign skin lesions.
  • Understanding cellular changes in melanocytic lesions is crucial for diagnosis.
  • Nuclear morphology provides insights into cellular activity and potential transformation.

Purpose of the Study:

  • To quantitatively analyze melanocyte nuclear morphometry in various acquired melanocytic nevi.
  • To investigate nuclear changes across different skin depths (epidermis, papillary dermis, reticular dermis).
  • To correlate nuclear morphometric parameters with the progression of melanocytic lesions.

Main Methods:

  • Morphometric evaluation of melanocyte nuclei from lentigines, junctional, compound, and intradermal nevi.

Related Experiment Videos

  • Analysis of nuclear parameters including area, perimeter, and shape (form Ar, form Ell).
  • Comparison of nuclear features at epidermal, papillary dermal, and reticular dermal levels.

    • Main Results:

    • Nuclear area and roundness (form Ell) progressively increased from lentigines to dermal nevi.
    • This trend was consistent across all skin levels studied.
    • In compound nevi, nuclei enlarged from epidermis to papillary dermis, then decreased towards the reticular dermis.
    • Nuclear roundness increased from epidermis to deeper dermal layers in compound and intradermal nevi.

    Conclusions:

    • Melanocyte nuclei enlarge and become rounder during the evolution from lentigo to dermal nevi, indicative of melanocytic maturation.
    • Epidermal nuclei in compound nevi are smaller and more elongated than papillary dermal nuclei.
    • Superficial dermal nuclei in compound and intradermal nevi are larger but less round than deeper ones.
    • These observed changes, termed melanocytic maturation, may also be influenced by local factors and share similarities with changes seen in malignant melanomas.