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Oxidative Stress Mediates Vascular Tortuosity.

Toshio Fumoto1, Shouhei Kinoshita1, Takao Sasaki1

  • 1Department of Neurosurgery, Graduate School of Medicine, Hirosaki University, 5-Zaifuchou, Hirosaki, Aomori 036-8562, Japan.

Antioxidants (Basel, Switzerland)
|July 2, 2021
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Oxidative stress significantly contributes to vascular tortuosity, a condition linked to various disorders. Antioxidant treatment shows promise in preventing and treating these permanent vessel changes.

Keywords:
apple polyphenoloxidative stressvascular tortuosity

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Area of Science:

  • Vascular Biology
  • Pathophysiology
  • Oxidative Stress

Background:

  • Vascular tortuosity is increasingly detected but its mechanisms remain unclear.
  • It is associated with various pathological conditions.
  • Understanding its origins is crucial for potential interventions.

Purpose of the Study:

  • To investigate the role of oxidative stress in the development of vascular tortuosity.
  • To test the hypothesis that oxidative stress mediates tortuous vessel generation.

Main Methods:

  • Induction of vascular tortuosity using the bilateral common carotid artery (CCA) ligation model in rats.
  • Analysis of gene expression related to oxidative stress via microarray and real-time PCR.
  • Evaluation of antioxidant treatment effects on tortuosity in a rabbit model.

Main Results:

  • Bilateral CCA ligation induced permanent basilar artery tortuosity in rats, more pronounced in adults.
  • Tortuosity correlated with the induction of oxidative stress-related genes.
  • Antioxidant treatment suppressed tortuous morphological changes in rabbits.

Conclusions:

  • Oxidative stress plays a significant role in the development of vascular tortuosity.
  • These findings suggest potential therapeutic strategies targeting oxidative stress for vascular tortuosity.
  • Further research is needed to fully elucidate the underlying mechanisms.