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An Orally Bioavailable (Mice) Prodrug of Glutathione
Daune L Crankshaw1, Jacquie E Briggs1, Robert Vince1
1Center for Drug Design, University of Minnesota, Minneapolis, MN 55455, USA.
Antioxidants (Basel, Switzerland)
|July 2, 2021
Abstract:
L-Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH), was found to be orally bioavailable in mice, and protected mice against a toxic dose of acetaminophen. If oral bioavailability can also be demonstrated in humans, a wide range of applicability for CySSG can be envisioned.

