Related Experiment Video
Updated: Oct 30, 2025
08:00
Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
Published on: October 11, 2019
7.7K
LncRNA FENDRR Expression Correlates with Tumor Immunogenicity
Maria Cristina Munteanu1, Sri Nandhini Sethuraman1, Mohit Pratap Singh1
1College of Veterinary Medicine, Physiological Sciences, Oklahoma State University, Stillwater, OK 74074, USA.
Genes
|July 2, 2021
Summary
FENDRR, a tumor suppressor long non-coding RNA, is linked to immune activation in cancer. Its expression predicts immune responsiveness and may enhance cancer immunotherapy by modulating inflammatory pathways.
Area of Science:
- Oncology
- Molecular Biology
- Immunology
Background:
- FENDRR (Fetal-lethal non-coding developmental regulatory RNA) is a long non-coding RNA (lncRNA) with identified tumor suppressor functions.
- FENDRR is implicated in the epigenetic regulation of genes associated with tumor immunity.
Purpose of the Study:
- To investigate the role of FENDRR in predicting cancer immune-responsiveness.
- To understand FENDRR's contribution to the inflammatory tumor microenvironment.
Main Methods:
- Assessment of FENDRR expression in murine tumor cell lines (C26 colon, 4T1 breast, B16F10 melanoma).
- Correlation analysis between FENDRR levels and immune activation gene expression, including MHC class I.
- Investigation of FENDRR's mechanistic role in modulating inflammatory and WNT signaling pathways.
Main Results:
- Tumor cells with high immune activation (C26, 4T1) showed high FENDRR expression.
- Tumor cells with suppressed immune gene expression (B16F10) exhibited low or undetectable FENDRR levels.
- Modulation of FENDRR expression influenced inflammatory and WNT signaling pathways in tumors.
Conclusions:
- FENDRR expression correlates with immune-relevant phenotypes in tumors.
- FENDRR may serve as a predictive biomarker for immune-responsiveness.
- FENDRR modulation holds potential for improving cancer immunotherapy outcomes.
Related Concept Videos
02:39lncRNA - Long Non-coding RNAs
9.2K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.2K
01:27Tumor Immunotherapy
783
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
783
02:07Tumor Progression
6.7K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.7K
01:30Cancer Vaccines
586
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
586
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
8.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.4K