PRF-Solution in Large Sinus Membrane Perforation with Simultaneous Implant Placement-Micro CT and Histological...

Area of Science:

• Dental Implantology
• Regenerative Medicine
• Oral and Maxillofacial Surgery

Background:

• Maxillary sinus floor elevation is crucial for posterior maxilla implant placement.
• Complicated cases involving sinus membrane perforation or prior infections pose challenges.
• Platelet-rich fibrin (PRF) is explored as a biomaterial for bone augmentation.

Purpose of the Study:

• To evaluate the efficacy of platelet-rich fibrin (PRF) as a sole grafting material in complex maxillary sinus floor elevation.
• To assess PRF's role in managing sinus membrane perforations during augmentation.
• To determine the success of simultaneous implant placement with PRF sinus augmentation.

Main Methods:

• Simultaneous maxillary sinus floor augmentation and implant insertion were performed.
• Platelet-rich fibrin (PRF) was used for membrane sealing and bone grafting.
• Radiological (CBCT), micro-CT, and histological analyses were conducted; implant survival was monitored for up to 4 years.

Main Results:

• Successful bone grafting and implant integration were achieved in all nine surgeries (19 implants).
• Significant new bone formation was evident at 12 months post-surgery.
• Mean bone height gain was 6.43 mm, with 52.30% vital bone and 50.32% bone/tissue volume ratio.

Conclusions:

• Platelet-rich fibrin (PRF) is a viable alternative for single-stage sinus augmentation, even in complicated scenarios.
• PRF facilitates successful bone regeneration and implant stability following sinus membrane perforation.
• This approach simplifies treatment for patients requiring posterior maxillary implants.