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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

454
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
454
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

469
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
469
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

486
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
486
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

580
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
580
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

269
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
269
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

282
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
282

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Related Experiment Video

Updated: Oct 30, 2025

Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

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Predicting Colorectal Cancer Occurrence in IBD.

Mehmet Yalchin1,2, Ann-Marie Baker2, Trevor A Graham2

  • 1Inflammatory Bowel Disease Department, St. Mark's Hospital, Watford R.d., Harrow HA1 3UJ, UK.

Cancers
|July 2, 2021
PubMed
Summary

Patients with inflammatory bowel disease (IBD) face higher colorectal cancer (CRC) risks. This review explores molecular factors to improve surveillance and risk stratification for colitis-associated CRC (CA-CRC).

Keywords:
cancer riskinflammatory bowel diseasemolecular biomarkersmolecular risk factorsrisk factors

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Area of Science:

  • Gastroenterology and Oncology
  • Molecular Biology and Pathology

Background:

  • Patients with colonic inflammatory bowel disease (IBD) have an elevated risk of colorectal cancer (CRC).
  • Current surveillance programs for colitis-associated CRC (CA-CRC) rely on clinical, endoscopic, and histological predictors.
  • Despite advances, further molecular understanding is needed for improved patient risk stratification.

Purpose of the Study:

  • To review known risk factors for CA-CRC.
  • To explore the molecular landscape relevant to CA-CRC progression.
  • To identify potential molecular markers for optimizing IBD surveillance programs.

Main Methods:

  • Literature review of risk factors for CA-CRC.
  • Exploration of current molecular research in CA-CRC.
  • Synthesis of findings to suggest improvements in surveillance strategies.

Main Results:

  • Significant progress has been made in understanding CA-CRC predictors.
  • Advances in endoscopy and medical care have led to a decline in CA-CRC incidence.
  • The molecular landscape offers potential for enhanced risk stratification.

Conclusions:

  • Enhanced molecular understanding can complement existing CA-CRC surveillance programs.
  • Improved risk stratification can lead to more personalized patient management.
  • Further research into molecular markers is crucial for optimizing IBD patient care.