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Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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RETRACTED: Meligy et al. Therapeutic Potential of Mesenchymal Stem Cells Versus Omega n - 3 Polyunsaturated Fatty Acids on Gentamicin-Induced Cardiac Degeneration. <i>Pharmaceutics</i> 2022, <i>14</i>, 1322.

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Correction: Mohite et al. Bioactive Compound-Fortified Nanomedicine in the Modulation of Reactive Oxygen Species and Enhancement of the Wound Healing Process: A Review. <i>Pharmaceutics</i> 2025, <i>17</i>, 855.

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Smart Nanoparticles for Chemo-Based Combinational Therapy.

Binita Shrestha¹, Lijun Wang¹, Eric M Brey¹

¹Department of Biomedical and Chemical Engineering, The University of Texas at San Antonio, San Antonio, TX 78249, USA.

|July 2, 2021

Summary

This summary is machine-generated.

Smart nanoplatforms offer advanced cancer treatment by combining therapies and responding to internal or external triggers for improved precision and outcomes.

Keywords:

cancer chemotherapy combinational multi-functional smart nanoparticles stimuli-responsive treatment

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Area of Science:

Oncology
Nanomedicine
Biotechnology

Background:

Cancer is a complex disease with limitations in traditional therapies, including low therapeutic index, resistance, and adverse effects.
Advancements in cancer biology and technology, particularly nanomedicine, are driving new therapeutic strategies.
Combinational regimens are crucial for effective cancer treatment, integrating various therapeutic modalities.

Purpose of the Study:

To review recent advancements in smart nanoplatforms for combinational cancer therapy.
To highlight the potential of stimuli-responsive nanoplatforms in improving cancer treatment precision.
To discuss the integration of different therapeutic approaches within nanomedicine frameworks.

Main Methods:

Review of current literature on nanomedicine applications in cancer therapy.
Analysis of smart nanoplatforms designed for combinational treatment strategies.
Investigation of stimuli-responsive mechanisms for targeted drug delivery and therapeutic enhancement.

Main Results:

Smart nanoplatforms integrating multiple therapeutic agents (chemo, gene, energy, immunology) show promise.
Nanoplatforms responsive to internal (pH, enzymes, hypoxia) and external (light, temperature, ultrasound, magnetic field) stimuli enhance precision therapy.
Combinational therapy using smart nanoplatforms represents a significant advancement in cancer treatment.

Conclusions:

Smart nanoplatforms for combinational therapy are poised to be the next generation of cancer treatment.
These platforms offer improved therapeutic outcomes by overcoming traditional therapy limitations.
Further research in smart nanomedicine is essential for optimizing precision cancer care.