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Silylated Tag-Assisted Peptide Synthesis: Continuous One-Pot Elongation for the Production of Difficult Peptides
Shinya Yano1, Toshihiro Mori1, Hideki Kubota1
1Iwate Drug Synthesis R&D Center, Sekisui Medical Co., Ltd., Iwate 028-7305, Japan.
Abstract:
Addition of the silylated tag (STag) enables peptides to be highly soluble in CPME, allowing them to be used at high concentrations in a coupling reaction to enhance reactivity and achieve effective synthesis of sterically hindered peptides. We described the development of a continuous one-pot STag-assisted peptide synthesis platform as a method that provides near-stoichiometric, speedy, environmentally friendly, and scalable peptide synthesis.

