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Updated: Oct 30, 2025

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

Published on: September 19, 2017

Metal-Based G-Quadruplex Binders for Cancer Theranostics.

Elisa Palma¹, Josué Carvalho², Carla Cruz²

¹C2TN-Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10, 2695-066 Bobadela LRS, Portugal.

Pharmaceuticals (Basel, Switzerland)

|July 2, 2021

Summary

Researchers are developing fluorescent metal complexes to visualize and target G-quadruplex (G4) DNA structures. These probes show promise for new cancer theranostic agents, combining diagnosis and therapy for improved patient outcomes.

Keywords:

G-quadruplexes cancer theranostics fluorescent probes metal complexes oncogene promoters radioprobes telomerase

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Area of Science:

* Medicinal Chemistry
* Molecular Biology
* Nanotechnology

Background:

* Fluorescent small molecules, including metal complexes, can selectively identify G-quadruplex (G4) DNA structures.
* This recognition capability enables the development of novel probes for visualizing G4 DNA within cellular environments.
* G4 structures are increasingly recognized for their roles in cellular processes and as potential targets in cancer therapy.

Purpose of the Study:

* To review recent advancements in developing novel cancer theranostic agents.
* Focus on metal-based fluorescent probes that exhibit specific G-quadruplex (G4) structure recognition.
* To explore the potential of G4-binders incorporating medical radiometals for nuclear medicine applications.

Main Methods:

* Comprehensive literature review of recent research on G4-targeting metal complexes.
* Analysis of studies focusing on copper (Cu), platinum (Pt), and ruthenium (Ru) complexes.
* Examination of potential applications of G4-binders with radiometals (e.g., 99mTc, 111In, 64Cu, 195mPt).

Main Results:

* Significant progress has been made in designing metal complexes for G4 structure recognition.
* Copper, platinum, and ruthenium complexes are prominent in this field.
* Integration of radiometals offers potential for theranostic applications in nuclear medicine.

Conclusions:

* Metal-based fluorescent probes targeting G-quadruplex (G4) structures are valuable tools for cancer theranostics.
* Further development of G4-binders with radiometals can enhance diagnostic and therapeutic capabilities.
* These probes hold promise for advancing precision medicine in oncology.