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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Cells of the Epidermis01:24

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The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Merkel Cell Polyomavirus Infection and Detection
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Merkel Cell Carcinoma.

Elena Dellambra1, Maria Luigia Carbone2, Francesca Ricci3

  • 1Molecular and Cell Biology Laboratory, IDI-IRCCS, 00167 Rome, Italy.

Biomedicines
|July 2, 2021
PubMed
Summary
This summary is machine-generated.

Merkel cell carcinoma (MCC), a rare skin cancer, is increasingly common. This review covers MCC epidemiology, diagnosis, and therapies, including promising immunotherapy for advanced cases.

Keywords:
Merkel cell carcinomaMerkel cell polyomavirusimmune checkpoint inhibitors

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Area of Science:

  • Oncology
  • Dermatology
  • Immunology

Background:

  • Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer with rising incidence.
  • Understanding MCC's epidemiology, pathogenesis, and clinical features is crucial for improved patient outcomes.

Purpose of the Study:

  • To provide a comprehensive review of Merkel cell carcinoma.
  • To evaluate current diagnostic and therapeutic strategies, including novel approaches.
  • To examine the role of immunotherapy and angiogenesis in MCC.

Main Methods:

  • Literature review of epidemiology, clinical features, pathogenesis, diagnosis, and therapies for MCC.
  • Analysis of immunological aspects and angiogenesis in MCC progression.
  • Review of clinical trials and outcomes for immune checkpoint inhibitors in advanced MCC.

Main Results:

  • MCC incidence is increasing globally.
  • Immune checkpoint inhibitors show effective results in treating advanced MCC.
  • Angiogenesis and angiogenic factors play a role in MCC progression.

Conclusions:

  • Significant progress has been made in understanding MCC pathology.
  • Further research is needed for effective diagnosis and therapeutic management.
  • Immunotherapy represents a promising avenue for advanced Merkel cell carcinoma treatment.