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Updated: Oct 30, 2025
Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
Published on: August 30, 2011
A Longitudinal Study of Episodic and Semantic Autobiographical Memory in aMCI and Alzheimer's Disease Patients
Juan C Meléndez1, Alfonso Pitarque2, Iraida Delhom3
1Department of Developmental and Educational Psychology, Faculty of Psychology, University of Valencia, Av. Blasco Ibañez 21, ES 46010 Valencia, Spain.
Background:
The main objective of this study was to analyze the evolution of autobiographical memory (both episodic and semantic) in patients with mild cognitive impairment, patients with Alzheimer's disease, and a healthy control group. We compared these groups at two time points: first, at baseline, and in a follow-up after 18 months.
Method:
Twenty-six healthy older adults, 17 patients with mild amnestic cognitive impairment, and 16 patients with Alzheimer's disease, matched on age and educational level, were evaluated at both time points with the Autobiographical Memory Interview.
Results:
The results showed significant longitudinal deterioration in episodic and semantic autobiographical memory in patients with mild cognitive impairment and in patients with Alzheimer's disease, but not in healthy older adults.
Conclusions:
The deterioration of episodic and semantic autobiographical memory in AD is confirmed; however, although the episodic was impaired in aMCI, a pattern that evolved toward deterioration over a period of eighteen months was observed for the semantic autobiographical memory.
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