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Updated: Oct 30, 2025

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
Published on: June 9, 2017
Ligands of Adrenergic Receptors: A Structural Point of View
Yiran Wu1, Liting Zeng1,2, Suwen Zhao1,2
1iHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Abstract:
Adrenergic receptors are G protein-coupled receptors for epinephrine and norepinephrine. They are targets of many drugs for various conditions, including treatment of hypertension, hypotension, and asthma. Adrenergic receptors are intensively studied in structural biology, displayed for binding poses of different types of ligands. Here, we summarized molecular mechanisms of ligand recognition and receptor activation exhibited by structure. We also reviewed recent advances in structure-based ligand discovery against adrenergic receptors.
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