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Nanoparticles as a Tool in Neuro-Oncology Theranostics
Andrea L Klein1, Grant Nugent2, John Cavendish2
1The George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA.
Pharmaceutics
|July 2, 2021
Summary
Nanomaterials show promise for neuroimaging in oncology and neurodegenerative diseases. This review covers their characteristics, toxicity, and use in various imaging techniques for brain tumor diagnosis.
Area of Science:
- Nanotechnology
- Biomedical Imaging
- Neuroscience
Background:
- Nanomaterials possess unique physicochemical properties.
- Nanomaterials offer potential for theranostic applications, including neuroimaging.
- Early detection of neurodegenerative changes and CNS malignancy is crucial.
Purpose of the Study:
- To review the imaging characteristics of various nanomaterials for neuro-oncology.
- To assess the toxicity profiles of nanomaterials used in neuroimaging.
- To explore mechanisms for enhancing nanoparticle tropism for brain targeting.
Main Methods:
- Systematic review of current evidence.
- Focus on carbon-based and metal oxide nanoparticles.
- Analysis of nanomaterial utility in MRI, CT, PET, SPECT, photoacoustic, and fluorescent imaging.
Main Results:
- Nanoparticles demonstrate potential as imaging agents in neuro-oncology.
- Various nanomaterials exhibit distinct imaging characteristics.
- Toxicity and tropism mechanisms require further investigation for clinical translation.
Conclusions:
- Nanoparticles are valuable tools for neuroimaging in oncology and neurodegenerative disease diagnosis.
- Further research into toxicity and targeted delivery is essential for clinical application.
- The theranostic potential of nanomaterials in neuro-oncology is significant.
