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The Role of Melatonin on NLRP3 Inflammasome Activation in Diseases

Burak Ibrahim Arioz1,2, Emre Tarakcioglu1,2, Melis Olcum1

  • 1Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, 35340 Izmir, Turkey.

Antioxidants (Basel, Switzerland)
|July 2, 2021
PubMed

Insights

Melatonin, a natural hormone, effectively suppresses the overactivated NLRP3 inflammasome, a key player in immune responses and various diseases. This review explores melatonin

Area of Science:

  • Immunology
  • Neuroscience
  • Endocrinology

Background:

  • The NLRP3 inflammasome is crucial for innate immunity, detecting pathogens and cellular stress.
  • Overactivation of the NLRP3 inflammasome is implicated in diseases like neurodegeneration, cardiac, pulmonary, and metabolic disorders.
  • Inhibiting NLRP3 inflammasome activation is a significant therapeutic goal.

Purpose of the Study:

  • To review the impact of melatonin on NLRP3 inflammasome activity.
  • To discuss the therapeutic potential of melatonin in disease contexts involving NLRP3 inflammasome dysregulation.

Main Methods:

  • Literature review of in vitro and in vivo studies.
  • Analysis of intracellular signaling pathways affected by melatonin.
  • Examination of melatonin's role in disease models.

Main Results:

  • Melatonin demonstrates significant ability to alleviate NLRP3 inflammasome activation.
  • Evidence suggests melatonin acts through multiple intracellular signaling pathways.
  • Melatonin's antioxidant and immunomodulatory properties contribute to its effects.

Conclusions:

  • Melatonin is a promising natural compound for modulating NLRP3 inflammasome activity.
  • Targeting the NLRP3 inflammasome with melatonin may offer therapeutic benefits for various diseases.
  • Further research into melatonin's mechanisms and clinical applications is warranted.
Keywords:
NLRP3 inflammasomediseasemelatonin

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