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Updated: Oct 30, 2025

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
Evaluating Functional Immunity Following Encapsulated Bacterial Infection and Vaccination
Zheng Quan Toh1,2, Rachel A Higgins1, Nadia Mazarakis1
1Murdoch Children's Research Institute, Parkville, VIC 3052, Australia.
Abstract:
Encapsulated bacteria such as Streptococcus pneumoniae, Haemophilus influenzae type b and Neisseria meningitidis cause significant morbidity and mortality in young children despite the availability of vaccines. Highly specific antibodies are the primary mechanism of protection against invasive disease. Robust and standardised assays that measure functional antibodies are also necessary for vaccine evaluation and allow for the accurate comparison of data between clinical studies. This mini review describes the current state of functional antibody assays and their importance in measuring protective immunity.
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