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Related Experiment Video

Updated: Oct 30, 2025

Author Spotlight: Low-Cost Electroencephalographic Recording System Combined with a Millimeter-Sized Coil to Transcranially Stimulate the Mouse Brain In Vivo
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Modular Data Acquisition System for Recording Activity and Electrical Stimulation of Brain Tissue Using Dedicated

Paweł Jurgielewicz1, Tomasz Fiutowski1, Ewa Kublik2

  • 1Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, al. A. Mickiewicza 30, 30-059 Krakow, Poland.

Sensors (Basel, Switzerland)
|July 2, 2021
PubMed
Summary
This summary is machine-generated.

We developed a versatile Data Acquisition (DAQ) system for simultaneous brain stimulation and recording. This system, utilizing Neurostim-3 ASICs and MEAs, efficiently captures neural data in real-time for advanced brain research.

Keywords:
ASICdata acquisitionelectrical stimulationmicroelectrodesneural interfacesneurophysiologysoftware engineering

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Signal Processing

Background:

  • Simultaneous recording and stimulation of neural activity is crucial for understanding brain function.
  • Existing systems often face limitations in channel count, real-time processing, and compatibility with various hardware.

Purpose of the Study:

  • To present a modular Data Acquisition (DAQ) system for simultaneous electrical stimulation and recording of brain activity.
  • To detail the hardware and software architecture, focusing on real-time performance and integration with Neurostim-3 ASIC and MEAs.
  • To characterize the Neurostim-3's signal processing capabilities for neural signal analysis.

Main Methods:

  • Development of a modular DAQ system with up to 512 bidirectional channels.
  • Integration with custom Neurostim-3 Application Specific Integrated Circuits (ASICs) and commercial Multi-Electrode Arrays (MEAs).
  • Real-time software design for seamless operation on a standard Personal Computer (PC) without precomputation.

Main Results:

  • The DAQ system supports simultaneous control of 512 independent input-output channels.
  • Neurostim-3 channels demonstrate signal gain linearity across a wide amplitude range.
  • High-pass cut-off frequency near 0.6Hz enables recording of Local Field Potentials (LFPs) and spiking activity.
  • Successful acquisition of physiological data from stimulated and non-stimulated rat brain tissue.

Conclusions:

  • The developed DAQ system, integrating Neurostim-3 and MEAs, offers efficient and effective simultaneous brain stimulation and recording.
  • The system's real-time processing capabilities and hardware compatibility provide valuable insights into brain information processing.
  • This technology is suitable for advanced neuroscience research, enabling detailed analysis of neural signals.