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pHEMA: An Overview for Biomedical Applications.

Mina Zare¹, Ashkan Bigham², Mohamad Zare³

¹Center for Nanotechnology and Sustainability, Department of Mechanical Engineering, National University of Singapore, Singapore 117581, Singapore.

International Journal of Molecular Sciences

|July 2, 2021

Summary

Poly(2-hydroxyethyl methacrylate) (pHEMA) is a biocompatible polymer with diverse biomedical uses, including tissue regeneration and drug delivery. Strategies to enhance pHEMA

Keywords:

antimicrobial strategies biomedical application cancer therapy contact lens ocular drug delivery pHEMA tissue engineering and regenerative medicine

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Area of Science:

Biomaterials Science
Polymer Chemistry
Biomedical Engineering

Background:

Poly(2-hydroxyethyl methacrylate) (pHEMA) exhibits excellent biocompatibility and low immunogenicity.
Its properties make it suitable for various biomedical applications.

Purpose of the Study:

To provide a comprehensive review of pHEMA's properties and applications.
To highlight pHEMA's role in bone tissue regeneration, wound healing, cancer therapy, and ophthalmic uses.
To discuss antimicrobial strategies and drug delivery applications of pHEMA.

Main Methods:

Literature review of state-of-the-art research on pHEMA.
Analysis of pHEMA's properties, including biocompatibility and cytocompatibility.
Examination of current and potential biomedical applications.

Main Results:

pHEMA is a versatile biomaterial for tissue engineering, drug delivery, and ophthalmic devices.
Pure pHEMA lacks antimicrobial properties, necessitating strategies like silver nanoparticles or antibiotics for infection prevention.
Antimicrobial strategies and drug delivery applications of pHEMA were specifically covered.

Conclusions:

pHEMA is a promising biomaterial with a bright future in advanced biomedical applications.
Further research will likely expand its use in regenerative medicine and therapeutic delivery systems.
Addressing the lack of antimicrobial properties is crucial for expanding pHEMA's clinical utility.