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EV Cargo Sorting in Therapeutic Development for Cardiovascular Disease

Cherrie D Sherman1, Shweta Lodha1, Susmita Sahoo1

  • 1Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, One Gustav L. Levy, P.O. Box 1030, New York, NY 10029, USA.

Cells
|July 2, 2021
PubMed

Insights

Extracellular vesicles (EVs) are crucial for cell communication and show promise for treating cardiovascular disease. Understanding EV cargo sorting and bioengineering are key to developing effective EV-based therapies.

Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Cardiovascular Research

Background:

  • Cardiovascular disease (CVD) is a leading global health concern, necessitating novel therapeutic strategies.
  • Extracellular vesicles (EVs) mediate intercellular communication by transferring bioactive molecules, reflecting cellular states.
  • EVs are emerging as promising therapeutic agents and drug delivery vehicles for various diseases, including CVD.

Purpose of the Study:

  • To review the mechanisms governing the sorting of molecules into EVs.
  • To explore methods for bioengineering EVs for therapeutic applications.
  • To discuss the potential of engineered EVs in treating cardiovascular disease.

Main Methods:

  • Literature review of EV biology, cargo sorting mechanisms, and bioengineering techniques.
  • Analysis of current research on EV-based therapies for cardiovascular conditions.
  • Synthesis of information on EV cargo sorting and engineering for therapeutic delivery.

Main Results:

  • EVs contain diverse biomolecules (proteins, genes, miRNAs) reflecting their cell of origin.
  • Understanding EV cargo sorting is crucial for designing targeted therapeutic delivery systems.
  • EV bioengineering offers a platform for developing next-generation treatments for cardiovascular disease.

Conclusions:

  • Engineered EVs hold significant potential as a therapeutic delivery system for cardiovascular disease.
  • Further research into EV cargo sorting and bioengineering will advance their clinical applications.
  • EVs represent a promising frontier in the development of novel cardiovascular therapies.

Keywords:
cardiovascular diseasecargo sorting pathogenesisdiagnosticsexosomesextracellular vesiclestherapeutics

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