Boswellic Acids Show In Vitro Activity against Leishmania donovani
Hippolyt L Greve1, Marcel Kaiser2,3, Pascal Mäser2,3
1Institute of Pharmaceutical Biology and Phytochemistry, University of Münster, Pharma Campus-Corrensstrasse 48, D-48149 Münster, Germany.
Abstract:
In continuation of our search for leads from medicinal plants against protozoal pathogens, we detected antileishmanial activity in polar fractions of a dichloromethane extract from Boswellia serrata resin. 11-keto-β-boswellic acid (KBA) could be isolated from these fractions and was tested in vitro against Leishmania donovani axenic amastigotes along with five further boswellic acid derivatives. 3-O-acetyl-11-keto-β-boswellic acid (AKBA) showed the strongest activity with an IC50 value of 0.88 µM against axenic amastigotes but was inactive against intracellular amastigotes in murine macrophages.
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