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Flow and function in machine-preserved kidneys.

D Sampson, H M Jun, P Walczak

    The British Journal of Surgery
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

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    Machine preservation flow rates do not predict kidney transplant success. Ignoring these flow rates could increase kidney availability for transplantation by 25%.

    Area of Science:

    • Nephrology
    • Transplantation immunology
    • Organ preservation

    Background:

    • Machine preservation is a standard method for donor kidney storage.
    • Donor kidney quality assessment is crucial for successful transplantation.
    • Flow rates during machine preservation are often used as a quality indicator.

    Purpose of the Study:

    • To evaluate the correlation between machine preservation flow rates and kidney transplant outcomes.
    • To determine if flow rates impact immediate function, long-term function, or rejection rates.
    • To assess the impact of disregarding flow rate criteria on kidney transplant availability.

    Main Methods:

    • Analysis of 100 machine-preserved cadaver kidney transplants.
    • Categorization of kidneys based on preservation flow rates (ml/min).

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  • Assessment of transplant function at 1, 3, and 12 months post-transplant.

    • Main Results:

    • No correlation found between flow rate and kidney function at any time point.
    • Kidneys with low flow rates (<100 ml/min or <80 ml/min) showed no difference in function compared to others.
    • Low flow was associated with prolonged acute tubular necrosis but did not impair eventual function.
    • Higher incidence of early aggressive rejection in immediately functioning kidneys.
    • Preservation failure was a rare cause of primary non-function.

    Conclusions:

    • Machine preservation flow rates are not predictive of kidney transplant success.
    • Current criteria for discarding kidneys based on flow rates may be unnecessarily restrictive.
    • Ignoring flow characteristics could increase the donor kidney pool by up to 25%.