Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rabies01:28

Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...
Coronavirus01:29

Coronavirus

Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alphavirus nsP3 as a multifunctional orchestrator of virus-host interplay.

Journal of virology·2026
Same author

Integrated reiterative pipeline for rapid epitope-based pan-alphavirus vaccines.

Science advances·2026
Same author

LRP8 is an entry receptor for tick-borne encephalitis viruses.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Standardization of Quantitative Plaque-Based Viral Assays for Orthoflavivirus Cacipacoré.

Viruses·2025
Same author

Rhesus macaques model human Mayaro virus disease and transmit to Aedes aegypti mosquitoes.

PLoS neglected tropical diseases·2025
Same author

Inside-out: modelling the link between Zika virus viral dynamics within hosts and transmission to vectors across host species and virus strains.

Journal of the Royal Society, Interface·2025

Related Experiment Video

Updated: Jun 27, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
11:36

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

22.2K

SARS-CoV-2 Infects Hamster Testes.

Rafael K Campos1, Vidyleison N Camargos2, Sasha R Azar2

  • 1Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.

Microorganisms
|July 2, 2021
PubMed
Summary

COVID-19 (SARS-CoV-2) may directly infect testicular cells, potentially explaining observed testicular damage and reduced testosterone levels in infected individuals. This study provides evidence of viral replication in hamster testes.

Keywords:
SARS-CoV-2Sertolihamsterreproductive tracttestes

More Related Videos

Production of Genetically Engineered Golden Syrian Hamsters by Pronuclear Injection of the CRISPR/Cas9 Complex
06:12

Production of Genetically Engineered Golden Syrian Hamsters by Pronuclear Injection of the CRISPR/Cas9 Complex

Published on: January 9, 2018

13.4K
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

3.0K

Related Experiment Videos

Last Updated: Jun 27, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
11:36

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

22.2K
Production of Genetically Engineered Golden Syrian Hamsters by Pronuclear Injection of the CRISPR/Cas9 Complex
06:12

Production of Genetically Engineered Golden Syrian Hamsters by Pronuclear Injection of the CRISPR/Cas9 Complex

Published on: January 9, 2018

13.4K
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

3.0K

Area of Science:

  • Virology
  • Reproductive Medicine
  • Infectious Diseases

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, primarily affects the respiratory system.
  • Emerging evidence suggests potential extrapulmonary manifestations, including effects on the male reproductive system.
  • Previous studies indicated testicular damage and altered testosterone levels post-SARS-CoV-2 infection, but mechanisms remain unclear, with limited evidence of viral replication in testicular tissue.

Purpose of the Study:

  • To investigate the potential for SARS-CoV-2 to infect and replicate within testicular cells.
  • To explore the direct impact of SARS-CoV-2 on testicular tissue, offering insights into observed pathologies.
  • To determine if direct viral infection contributes to testicular damage and hormonal dysfunction in COVID-19.

Main Methods:

  • Infection of golden Syrian hamsters intranasally to model mild human COVID-19.
  • Detection of viral RNA in testicular samples at various time points post-infection.
  • Utilizing an ex vivo model to assess SARS-CoV-2 replication in isolated hamster testicular cells.

Main Results:

  • Viral RNA (SARS-CoV-2) was detected in hamster testes up to one month post-infection.
  • No significant histopathological changes were observed in the testes despite viral RNA presence.
  • SARS-CoV-2 demonstrated replication in hamster testicular cells within an ex vivo experimental setup.

Conclusions:

  • Direct infection of testicular cells by SARS-CoV-2 is possible.
  • This direct infection may contribute to the testicular damage and dysfunction seen in some severe COVID-19 cases.
  • The findings suggest a potential direct mechanism linking SARS-CoV-2 to male reproductive health issues.