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Related Concept Videos

Bacterial Signaling01:30

Bacterial Signaling

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Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
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Gene Regulation in Microbial Communities: Quorum Sensing01:28

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Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
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Other Stress Responses in Bacteria01:30

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Bacteria have global regulatory systems that control several types of stress mechanisms. These include Pho regulon and the heat shock response, which are essential systems for environmental adaptation, such as nutrient limitation and proteotoxic stress. The Pho regulon and the heat shock response exemplify bacterial resilience, enabling rapid adaptation to fluctuating environmental conditions.Pho RegulonBacteria require phosphorus for essential cellular processes, including nucleic acid...
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Autocrine Signaling01:01

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Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
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Chemical Signaling in the Endocrine System01:08

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A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
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Types of Signaling Molecules01:32

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In multicellular organisms, many molecules transmit signals between cells to pass information. These signals vary in complexity and include small peptides, nucleotides, steroids, fatty acid derivatives, and dissolved gases such as nitric oxide. Some signaling molecules diffuse through the plasma membrane to act locally between neighboring cells or travel long distances. Others remain attached to the cell surface, transmitting information to other cells only when they make contact. In some...
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Related Experiment Video

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Humanized Mediator Release Assay as a Read-Out for Allergen Potency
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Histamine: A Bacterial Signal Molecule.

Tino Krell1, José A Gavira2, Félix Velando1

  • 1Department of Environmental Protection, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Prof. Albareda 1, 18008 Granada, Spain.

International Journal of Molecular Sciences
|July 2, 2021
PubMed
Summary

Histamine acts as a crucial inter-domain signal molecule, influencing communication between bacteria and hosts. Research shows bacteria can sense and produce histamine, impacting host immunity and virulence.

Keywords:
Pseudomonas aeruginosachemotaxisgut microbiomehistaminehistamine receptorssensingsignal molecule

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Area of Science:

  • Microbiology
  • Immunology
  • Biochemistry

Background:

  • Bacteria utilize sophisticated signaling for inter-domain communication.
  • Histamine is a vital signaling molecule in humans, regulating neurotransmission and immune responses.
  • Emerging evidence suggests histamine also mediates inter-domain and inter-species signaling.

Purpose of the Study:

  • To review current data on histamine's role as an inter-domain signaling molecule.
  • To explore bacterial sensing and synthesis of histamine.
  • To discuss the implications of bacterial histamine in host interactions.

Main Methods:

  • Literature review of recent studies on histamine signaling.
  • Analysis of research on bacterial histamine sensing mechanisms.
  • Examination of studies on bacterial histamine synthesis and secretion.

Main Results:

  • Bacteria possess mechanisms to sense histamine and its metabolites.
  • Histamine sensing in *Pseudomonas aeruginosa* influences chemoattraction and virulence gene expression.
  • Many bacteria synthesize and secrete histamine, affecting host immune responses and potentially causing pathology.

Conclusions:

  • Histamine is an emerging inter-domain signaling molecule with significant roles in host-microbe interactions.
  • Bacterial histamine production can modulate host immunity and contribute to disease.
  • Further research is needed to fully understand the general nature and implications of histamine as an inter-domain signal.